This easy ham and vegetable casserole is made with diced ham, frozen mixed vegetables, cream of mushroom soup, and sour cream and is topped with a layer of Bisquick.
A ham and vegetable casserole is a filling dish with savory flavors that the whole family will enjoy, making it a great recipe for a satisfying family dinner. It's a complete meal in a casserole dish.
The main ingredients of this creamy sauce are cream of mushroom soup, sour cream, shredded cheddar cheese, and shredded Monterey Jack cheese. Add a layer of Bisquick on top that bakes to golden brown perfection on top of the casserole.
The versatility of a ham and vegetable casserole extends beyond these ingredients. You can easily make this with chicken, leftover Thanksgiving turkey, ground beef, and more. If you like this vegetable casserole recipe, try chicken and stuffing casserole or green bean tater tot casserole.
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- Easy recipe: This is an easy casserole with simple ingredients from your pantry.
- Quick: Prep this dish in 10 minutes or less, and bake for 30 minutes.
- Leftover ham casserole: This is a great dish for using leftover ham from Easter, Thanksgiving, or Christmas dinner.
- Frozen mixed vegetables: A frozen blend of assorted vegetables, typically peas, carrots, corn, and green beans. Alternatively, you can make your own mix with the frozen veggies you have on hand.
- Cooked ham, diced: Diced (or cubed) pieces of pre-cooked ham. Leftover ham is perfect for this ham casserole recipe, but you can also find pre-cooked ham in the refrigerated meat section near bacon and lunch meats. Ham steak, cubed ham, or diced ham are what you're looking for.
- Condensed cream of mushroom soup: A thick and creamy soup made with mushrooms, used to create a rich and savory base for the casserole.
- Sour cream: Adds a tangy flavor and a creamy texture to the creamy ham filling.
- Shredded sharp cheddar cheese: This adds a sharp and cheesy taste.
- Monterey Jack cheese: This is a mild cheese the melts very well for a smooth texture.
- Onion powder: For a hint of onion flavor.
- Ground black pepper: To enhance the flavors of the dish.
- Bisquick: Bisquick is a pre-made baking mix that creates a bread or biscuit-like topping for the casserole.
- Milk: Whole milk to mix with the Bisquick and add moisture.
- Large egg: A binding agent for the structure of the top layer.
- Vegetable oil: Adds moisture to the Bisquick.
See the recipe card for quantities.
Preheat oven to 400ºF (200ºC). Grease an 8 by 8-inch baking dish and set aside.
In a medium mixing bowl, combine the mixed vegetables, cubed ham, cream of mushroom soup, sour cream, shredded cheese, onion powder, and pepper.
Spread the ham and veggie mixture evenly into the prepared casserole dish.
In a small mixing bowl, combine the Bisquick, milk, egg, and vegetable oil until smooth.
Pour the Bisquick mixture evenly over the ham and veggie mixture, gently spreading it from edge to edge.
Bake uncovered for 30 minutes or until the top is golden brown and a toothpick inserted into the Bisquick layer comes out clean. If it becomes too brown before the Bisquick layer is done cooking, cover the top of the casserole in aluminum foil.
- Frozen mixed vegetables: Substitute with your preferred blend of frozen veggies. For example, frozen peas and carrots are perfect for this casserole. You can also use canned veggies.
- Cooked ham: Replace with cooked turkey or chicken for a different flavor profile.
- Condensed cream of mushroom soup: Use your favorite "cream of" soup such as cream of chicken soup, cream of potato soup, or cream of celery soup. You can even use condensed cheddar cheese soup.
- Sour cream: Replace the sour cream with milk (this will result in a thinner sauce) or use Greek yogurt.
- Cheese: Use shredded Gruyère, Swiss cheese, smoked Gouda, pepper jack cheese, Colby Jack, provolone, or mozzarella. All of these are great options for a cheesy ham casserole.
- Onion powder: Substitute with garlic powder or omit.
- Bisquick: Make a homemade baking mix using flour, baking powder, salt, and a little butter or vegetable shortening as an alternative. Otherwise, you can use any brand of baking mix like Pearl Milling Company.
- Milk: Whole milk will add the most moisture because of the fat content, but low-fat milk or skim milk will also work in this recipe.
- Vegetable oil: Canola oil is a great substitute for vegetable oil. Olive oil will work but it is not my top recommendation.
Stuffing casserole: Replace the Bisquick layer with a prepared box of stuffing. See this easy chicken stuffing casserole for inspiration.
Cornbread casserole: Replace the Bisquick layer with a prepared box of cornbread (1 box Jiffy Corn Muffin Mix, ⅓ cup milk, and 1 large egg). See this Mexican cornbread casserole for inspiration.
Biscuit casserole: Use kitchen scissors to cut up refrigerated biscuit dough into small pieces and evenly cover the top of the casserole. Bake until the biscuit pieces are golden and cooked through.
Noodle bake: For a ham and cheese pasta bake, try this colorful macaroni casserole.
- 8x8 baking dish - To bake the casserole. You can also use a 9 by 9 inch baking dish.
- Mixing bowls - A medium mixing bowl to mix the ham mixture and a small mixing bowl for the Bisquick topping.
Transfer the leftover ham casserole into an airtight container or cover the baking dish tightly with plastic wrap or foil. Refrigerate for 3-4 days for optimal freshness or freeze for up to 2-3 months.
Ham and Vegetable Casserole
- 2 cups frozen mixed vegetables
- 1-½ cups cooked ham diced
- 1 can condensed cream of mushroom soup 10.5 ounces
- ½ cup sour cream
- ½ cup shredded sharp cheddar cheese
- ½ cup Monterey Jack cheese
- 1 teaspoon onion powder
- ½ teaspoon ground black pepper
- 1 cup Bisquick
- ½ cup milk
- 1 large egg
- 1 tablespoon vegetable oil
- Preheat oven to 400ºF (200ºC). Grease an 8 by 8-inch baking dish and set aside.
- In a medium mixing bowl, combine the mixed vegetables, cubed ham, cream of mushroom soup, sour cream, shredded cheese, onion powder, and pepper. Spread the ham and veggie mixture evenly into the prepared casserole dish.
- In a small mixing bowl, combine the Bisquick, milk, egg, and vegetable oil until smooth. Pour the Bisquick mixture evenly over the ham and veggie mixture, gently spreading it from edge to edge.
- Bake uncovered for 30 minutes or until the top is golden brown and a toothpick inserted into the Bisquick layer comes out clean. If it becomes too brown before the Bisquick layer is done cooking, cover the top of the casserole in aluminum foil.